Ipamorelin
A selective growth-hormone secretagogue with a clean side-effect profile.
Overview
Ipamorelin triggers the pituitary to release growth hormone (GH) by activating the ghrelin receptor, without notably raising cortisol or prolactin. It reached human trials (post-surgical bowel recovery) but was never approved.
How it works
Ghrelin-receptor (GHS-R1a) agonist producing a short, pulsatile GH release. Often paired with a GHRH analog (CJC-1295, sermorelin) for a stronger combined pulse.
Evidence
3/5
Phase 2 human trials for postoperative ileus; GH-release effects are well documented in humans.
Half-life
About 2 hours
Known as
NNC 26-0161
Compound facts
- Type
- Synthetic pentapeptide
- CAS Number
- 170851-70-4
- Molecular Weight
- 711.85 g/mol
- Amino Acids
- 5
- Sequence
- Aib-His-D-2-Nal-D-Phe-Lys-NH2
- Formula
- C38H49N9O5
Reported benefits
Raises GH and IGF-1
Dose-dependent GH release confirmed in human pharmacology studies.
Sleep quality
Frequently reported when dosed before bed.
Body composition
Leaner mass / less fat reported; controlled evidence is limited.
Bone density
Seen in animal studies.
“Anecdotal” means reported by users, not shown in controlled trials.
Community-reported regimens
Not recommendations. These are commonly cited ranges, shown so you can see what real-world use looks like.
| Plan | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
| Standard Inject on an empty stomach (2h after food); fasted state improves GH release. | 200 mcg | 1–3× daily (often bedtime) | 8–12 weeks | Subcutaneous |
| Higher | 300 mcg | 2× daily | 8–12 weeks, then break | Subcutaneous |
Reconstitution calculator
Set up for Ipamorelin. Switch peptide or vial size any time.
1Mix
Add 2 mL water for 5 mg/mL
2Draw
Draw to 4 units = 0.04 mL = 200 mcg
Drag the plunger to set your dose.
3Inject
Next site
Right belly, upper
Tap a site after you inject to keep a rotation.
Pinch the skin, stay 2 in. from the navel, then into a sharps bin.
- Doses per vial
- 50
- Vial lasts
- 35 days
- Good once mixed
- ~30 days
- Syringe
- 30-unit, 0.3 mL
The vial outlasts its ~30-day shelf life once mixed. A smaller vial wastes less.
Under 5 units is hard to measure accurately. Add more diluent for an easier draw.
Math only: concentration (mg/mL) = vial mg ÷ mL of water; units = dose (mg) ÷ concentration × 100. Always double-check against your own vial label and a clinician. This tool does not recommend a dose.
Reconstitution
Diluent: Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial.
- Wipe both vial tops with an alcohol swab and let dry.
- Draw the diluent, then inject it slowly down the inside wall of the vial — never straight onto the powder.
- Swirl gently or let it sit; do not shake. Foam can damage peptides.
- Solution should be clear. Cloudy, stringy or discolored = discard.
- Common mix: 5 mg + 2.5 mL = 2 mg/mL (200 mcg = 10 units).
Storage
Powder
Freezer / fridge
Keep sealed vial in the freezer (−20 °C) for long-term storage; fridge (2–8 °C) is fine for a few weeks. Keep dry and out of light.
After mixing
~30 days
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light.
Travel
Keep cool
Short trips at room temperature are generally fine for powder; keep mixed vials cold.
- Protect from light.
Side effects & cautions
Reported side effects
- Head rush / flushing right after injection
- Mild water retention
- Increased hunger
- Dizziness
Cautions
- Raises IGF-1 — avoid with active cancer or a history of it.
- May affect blood sugar; monitor if diabetic.
- Prohibited by WADA.
FDA & international status
Not FDA-approved
Investigational only. Not an approved drug; compounding status has changed over time, so verify with the FDA 503A categories page.
Regulations change often — verify with the FDA, EMA, MHRA, Health Canada, TGA and WADA before acting.
Often paired with
CJC-1295 (no DAC) + IpamorelinAlready sold as a blend — a GHRH + GHRP pairing for synergy.
Where to buy
| Size | Price | Per mg | Stock | Latest COA |
|---|---|---|---|---|
| 10 mg | $49.99 | $5.00 | In stock | 99.79% pure, lot IPA0002 ILS Labs, tested 2026-07-30 |
Amino Club list prices as of 2026-10-07, before promo codes. Multi-buy: 2+ units 5% off, 3+ units 7.5% off, 10+ units 40% off. Prices change; confirm on the product page. Mixing? Their bacteriostatic water is Amino H2O from $19.99.
Ipamorelin at Amino Club
Check sizes, current price and the certificate of analysis (COA) on the product page. Sold for in-vitro research only.
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- Look for a batch-specific COA with HPLC purity (≥98%) and mass-spec identity.
- Typical vial sizes: 2, 5, 10 mg.
FAQ
Will it raise cortisol like GHRP-6?
In studies, ipamorelin is notable for not meaningfully raising cortisol or prolactin at normal doses.
Why dose before bed?
Natural GH peaks during deep sleep; a fasted pre-sleep dose may reinforce that.