Pinealon
A three-amino-acid Khavinson 'bioregulator' aimed at the brain.
Overview
Pinealon is a tiny synthetic peptide (Glu-Asp-Arg) from Vladimir Khavinson's group in St. Petersburg, the same team behind Epithalon. It is promoted for memory, brain protection and sleep. Almost all research comes from that one group, mostly in cells and animals. There is no controlled human trial.
How it works
Proposed to enter cells and interact with DNA to influence gene activity, and to reduce oxidative stress in neurons. These ideas come mainly from the developers' lab and are not independently confirmed.
Evidence
2/5
Cell and animal studies from the developing group; one small uncontrolled human cohort. No placebo-controlled trials.
Half-life
Not well characterised; likely short
Known as
EDR, Glu-Asp-Arg
Compound facts
- Type
- Short peptide bioregulator (tripeptide)
- CAS Number
- 175175-23-2
- Molecular Weight
- 418.40 g/mol (C15H26N6O8)
- Amino Acids
- 3 (Glu-Asp-Arg)
- Sequence
- Glutamyl-Aspartyl-Arginine (EDR)
Reported benefits
Protects neurons from oxidative stress
Reduced reactive-oxygen buildup and cell death in cultured neurons.
Brain protection in animals
Reported benefits in rodent models of stress and low oxygen.
Memory and focus
One small open-label human group; no placebo arm.
Sleep and clarity
Common user reports.
“Anecdotal” means reported by users, not shown in controlled trials.
Community-reported regimens
Not recommendations. These are commonly cited ranges, shown so you can see what real-world use looks like.
| Plan | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
| Community Range 100–300 mcg. Some protocols use 1–2 mg daily for 10 days; there is no established human dose. | 200 mcg | Once daily | 10–20 days, then a break of 1–3 months | Subcutaneous |
Reconstitution calculator
Set up for Pinealon. Switch peptide or vial size any time.
1Mix
Add 2 mL water for 5 mg/mL
2Draw
Draw to 4 units = 0.04 mL = 200 mcg
Drag the plunger to set your dose.
3Inject
Next site
Right belly, upper
Tap a site after you inject to keep a rotation.
Pinch the skin, stay 2 in. from the navel, then into a sharps bin.
- Doses per vial
- 50
- Vial lasts
- 50 days
- Good once mixed
- ~30 days
- Syringe
- 30-unit, 0.3 mL
The vial outlasts its ~30-day shelf life once mixed. A smaller vial wastes less.
Under 5 units is hard to measure accurately. Add more diluent for an easier draw.
Math only: concentration (mg/mL) = vial mg ÷ mL of water; units = dose (mg) ÷ concentration × 100. Always double-check against your own vial label and a clinician. This tool does not recommend a dose.
Reconstitution
Diluent: Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial.
- Wipe both vial tops with an alcohol swab and let dry.
- Draw the diluent, then inject it slowly down the inside wall of the vial — never straight onto the powder.
- Swirl gently or let it sit; do not shake. Foam can damage peptides.
- Solution should be clear. Cloudy, stringy or discolored = discard.
- Common mix: 10 mg + 5 mL = 2 mg/mL (200 mcg = 10 units).
Storage
Powder
Freezer / fridge
Keep sealed vial in the freezer (−20 °C) for long-term storage; fridge (2–8 °C) is fine for a few weeks. Keep dry and out of light.
After mixing
~30 days
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light.
Travel
Keep cool
Short trips at room temperature are generally fine for powder; keep mixed vials cold.
Side effects & cautions
Reported side effects
- Injection-site irritation
- Mild headache
- Vivid dreams or sleep changes (reported)
Cautions
- Evidence comes almost entirely from the group that created it.
- No long-term safety data.
- Talk to a doctor first if you have a seizure disorder or take psychiatric medication.
FDA & international status
Not FDA-approved
Never approved or submitted. Sold as a research chemical in the US.
Regulations change often — verify with the FDA, EMA, MHRA, Health Canada, TGA and WADA before acting.
Often paired with
EpithalonBoth are Khavinson bioregulators and are often run in the same short course. No combined studies.
Where to buy
| Size | Price | Per mg | Stock | Latest COA |
|---|---|---|---|---|
| 10 mg | $49.99 | $5.00 | In stock | 99.52% pure, lot PIN0001 ILS Labs, tested 2026-08-12 |
Amino Club list prices as of 2026-10-07, before promo codes. Multi-buy: 2+ units 5% off, 3+ units 7.5% off, 10+ units 40% off. Prices change; confirm on the product page. Mixing? Their bacteriostatic water is Amino H2O from $19.99.
Pinealon at Amino Club
Check sizes, current price and the certificate of analysis (COA) on the product page. Sold for in-vitro research only.
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- Look for a batch-specific COA with HPLC purity (≥98%) and mass-spec identity.
- Typical vial sizes: 10 mg.
FAQ
How is it different from Epithalon?
Same research group, different peptide. Epithalon (four amino acids) is aimed at aging and the pineal gland; Pinealon (three) is pitched more at brain function. Both have thin, mostly in-house evidence.
Why short courses?
Khavinson-style protocols use brief courses of 10–20 days a few times a year rather than continuous use. That pattern comes from tradition, not head-to-head trials.
Can it be taken orally?
Oral Khavinson peptide capsules exist, and the developers claim short peptides survive digestion. That is not well proven; the vial is meant for injection.