PT-141
Works through the brain, not blood flow — and it's FDA-approved for women.
Overview
PT-141 (bremelanotide) activates melanocortin receptors in the central nervous system to increase sexual desire. Approved by the FDA in 2019 as Vyleesi for premenopausal women with hypoactive sexual desire disorder (HSDD). Used off-label by men.
How it works
Melanocortin-4 receptor agonist in the hypothalamus; acts on desire pathways rather than vascular function.
Evidence
4/5
Phase 3 RCTs in women (RECONNECT) led to FDA approval; men's data is smaller.
Half-life
About 2–3 hours
Known as
Bremelanotide, Vyleesi
Compound facts
- Type
- Cyclic heptapeptide
- CAS Number
- 189691-06-3
- Molecular Formula
- C50H68N14O10
- Molecular Weight
- 1025.2 g/mol
- Amino Acids
- 7 residues
- Sequence
- Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Reported benefits
Increased desire (women)
Significant improvement vs placebo in Phase 3 trials.
Erectile function / desire (men)
Positive results in trials, including some nonresponders to PDE5 inhibitors.
“Anecdotal” means reported by users, not shown in controlled trials.
Community-reported regimens
Not recommendations. These are commonly cited ranges, shown so you can see what real-world use looks like.
| Plan | Dose | Frequency | Duration | Route |
|---|---|---|---|---|
| FDA label (Vyleesi) Label dose for women. | 1750 mcg | As needed, ≥45 min before activity; max 1 dose per 24 h, 8 per month | As needed | Subcutaneous (abdomen/thigh) |
| Community (men & women) Range 0.5–2 mg. Start at 0.5–1 mg to check nausea. | 1000 mcg | As needed, 45–90 min before | Start low | Subcutaneous |
Reconstitution calculator
Set up for PT-141. Switch peptide or vial size any time.
1Mix
Add 2 mL water for 5 mg/mL
2Draw
Draw to 20 units = 0.2 mL = 1 mg
Drag the plunger to set your dose.
3Inject
Next site
Right belly, upper
Tap a site after you inject to keep a rotation.
Pinch the skin, stay 2 in. from the navel, then into a sharps bin.
- Doses per vial
- 10
- Vial lasts
- 70 days
- Good once mixed
- ~28 days
- Syringe
- 30-unit, 0.3 mL
The vial outlasts its ~28-day shelf life once mixed. A smaller vial wastes less.
Math only: concentration (mg/mL) = vial mg ÷ mL of water; units = dose (mg) ÷ concentration × 100. Always double-check against your own vial label and a clinician. This tool does not recommend a dose.
Reconstitution
Diluent: Bacteriostatic water (0.9% benzyl alcohol) — allows multiple draws from one vial.
- Wipe both vial tops with an alcohol swab and let dry.
- Draw the diluent, then inject it slowly down the inside wall of the vial — never straight onto the powder.
- Swirl gently or let it sit; do not shake. Foam can damage peptides.
- Solution should be clear. Cloudy, stringy or discolored = discard.
- Common mix: 10 mg + 2 mL = 5 mg/mL (1 mg = 20 units).
Storage
Powder
Freezer / fridge
Keep sealed vial in the freezer (−20 °C) for long-term storage; fridge (2–8 °C) is fine for a few weeks. Keep dry and out of light.
After mixing
~28 days
Refrigerate at 2–8 °C. Never freeze after mixing. Keep upright, capped, and out of light.
Travel
Keep cool
Short trips at room temperature are generally fine for powder; keep mixed vials cold.
Side effects & cautions
Reported side effects
- Nausea (very common, ~40%)
- Flushing
- Headache
- Temporary blood-pressure rise
- Skin darkening with repeated use
Cautions
- Raises blood pressure temporarily — avoid with uncontrolled hypertension or cardiovascular disease.
- Do not use more than once in 24 hours.
- Nausea can be severe at higher doses.
FDA & international status
FDA-approved (Vyleesi, 2019) for premenopausal women with HSDD
Approved for a specific female indication via a prescription auto-injector. Research vials are not the approved product, and use in men is off-label.
Regulations change often — verify with the FDA, EMA, MHRA, Health Canada, TGA and WADA before acting.
Where to buy
PT-141 vials
| Size | Price | Per mg | Stock | Latest COA |
|---|---|---|---|---|
| 10 mg | $29.99 | $3.00 | In stock | 99.91% pure, lot PT0002 ILS Labs, tested 2026-07-30 |
PT-141 nasal spray (ready-made)
View ↗| Size | Price | Per mg | Stock | Latest COA |
|---|---|---|---|---|
| 15 mg | $54.99 | $3.67 | Out of stock | 99.75% pure, lot SPT0001 ILS Labs, tested 2026-08-12 |
Amino Club list prices as of 2026-10-07, before promo codes. Multi-buy: 2+ units 5% off, 3+ units 7.5% off, 10+ units 40% off. Prices change; confirm on the product page. Mixing? Their bacteriostatic water is Amino H2O from $19.99.
PT-141 at Amino Club
Check sizes, current price and the certificate of analysis (COA) on the product page. Sold for in-vitro research only.
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An email when its price drops, a sale starts, or its FDA or WADA status changes.
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- Look for a batch-specific COA with HPLC purity (≥98%) and mass-spec identity.
- Typical vial sizes: 10 mg.
FAQ
Does it work like Viagra?
No. It acts on desire in the brain rather than blood flow.